PROBEmer: a web-based software tool for selecting optimal DNA oligos
نویسندگان
چکیده
منابع مشابه
Selecting Optimum DNA Oligos for Microarrays
High-density DNA oligo microarrays are widely used in biomedical research. In this paper we describe algorithms to optimize the selection of specific probes for each gene in an entire genome. Having optimized probes for each gene is valuable for two reasons. By minimizing background hybridization they provide more accurate determinations of true expression levels. And having optimum probes elim...
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MOTIVATION High density DNA oligo microarrays are widely used in biomedical research. Selection of optimal DNA oligos that are deposited on the microarrays is critical. Based on sequence information and hybridization free energy, we developed a new algorithm to select optimal short (20-25 bases) or long (50 or 70 bases) oligos from genes or open reading frames (ORFs) and predict their hybridiza...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gkg569